QuickView for PES1;jsessionid=F7402770BB61156DD2B37E9C7D478CE9 (gene)

Gene Symbol:

PES1 Homo sapiens

Full name:

pescadillo ribosomal biogenesis factor 1

Synonyms:

NOP7, PES, pescadillo homolog, pescadillo homolog 1, containing BRCT domain

Genomic Location:

Chr 22: 29302612-29317894

Description:

This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an im...

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This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACGTG_MYC_Q2 ,  ARNT_02 ,  CYTAGCAAY_UNKNOWN ,  MYCMAX_B ,  RFX1_01 ,  TCCCRNNRTGC_UNKNOWN ,  HIF1_Q5 ,  NMYC_01 ,  HIF1_Q3

Cytogenetic Map:

22q12.2

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