QuickView for PEX14;jsessionid=583065620E0EA563108DD8AC19DC7E21 (gene)

Gene Symbol:

PEX14 Homo sapiens

Full name:

peroxisomal biogenesis factor 14

Synonyms:

NAPP2, PBD13A, Pex14p, dJ734G22.2, peroxisomal membrane protein PEX14, NF-E2 associated polypeptide 2, PTS1 receptor docking protein, peroxin-14, peroxisomal membrane anchor protein PEX14, peroxisomal membrane anchor protein Pex14p

Genomic Location:

Chr 1: 10457590-10613402

Description:

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts...

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This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  SP1_Q4_01 ,  GGGCGGR_SP1_Q6 ,  SP1_Q6 ,  SP1_Q6_01

Cytogenetic Map:

1p36.22

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