QuickView for PFKFB3 (gene)

Gene Symbol:

PFKFB3 Homo sapiens

Full name:

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Synonyms:

IPFK2, PFK2, iPFK-2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase, 6PF-2-K/Fru-2,6-P2ase 3, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme, PFK/FBPase 3, fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase, inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, renal carcinoma antigen NY-REN-56

Genomic Location:

Chr 10: 6284901-6317501

Description:

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6B...

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The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  TGANTCA_AP1_C ,  MYC_Q2 ,  FOXO4_01 ,  YRTCANNRCGC_UNKNOWN ,  CACGTG_MYC_Q2 ,  GGGACCA_MIR133A_MIR133B ,  TACTTGA_MIR26A_MIR26B ,  TTGCACT_MIR130A_MIR301_MIR130B ,  AP2_Q6_01 ,  SP3_Q3 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  RNGTGGGC_UNKNOWN ,  NMYC_01 ,  TTGTTT_FOXO4_01 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  USF2_Q6 ,  PAX2_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-140

Cytogenetic Map:

10p15.1

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