QuickView for PGGT1B (gene)

Gene Symbol:

PGGT1B Homo sapiens

Full name:

protein geranylgeranyltransferase type I subunit beta

Synonyms:

BGGI, GGTI, geranylgeranyl transferase type-1 subunit beta, CTC-428G20.3, GGTase-I-beta, geranylgeranyl transferase type I subunit beta, geranylgeranyltransferase type I beta subunit, protein geranylgeranyltransferase type I, beta subunit, type I protein geranyl-geranyltransferase subunit beta

Genomic Location:

Chr 5: 114575476-114626449

Description:

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a...

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Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA1_03 ,  AAGCCAT_MIR135A_MIR135B ,  GATA1_04 ,  STAT_Q6 ,  AP4_01 ,  GR_Q6 ,  LMO2COM_02

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-30

Cytogenetic Map:

5q22.3

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