QuickView for PHB (gene)

Gene Symbol:

PHB Homo sapiens

Full name:

prohibitin

Synonyms:

HEL-215, HEL-S-54e, PHB1, prohibitin, epididymis luminal protein 215, epididymis secretory sperm binding protein Li 54e

Genomic Location:

Chr 17: 44836419-44847241

Description:

This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing result...

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This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  TGACCTY_ERR1_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  ERR1_Q2

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-27

Cytogenetic Map:

17q21.33

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