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QuickView for PHGDH (gene)

Gene Symbol:
PHGDH Homo sapiens Homo sapiens
Full name:
phosphoglycerate dehydrogenase
3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA, D-3-phosphoglycerate dehydrogenase, 2-oxoglutarate reductase, 3-phosphoglycerate dehydrogenase, epididymis secretory protein Li 113, malate dehydrogenase
Genomic Location:
Chr 1: 120056033-120088361
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retar...
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1

GO Molecular Function

oxidoreductase activity, acting on CH-OH group of donors | cofactor binding | nucleotide binding | coenzyme binding | catalytic activity | malate dehydrogenase activity | phosphoglycerate dehydrogenase activity | electron transfer activity | L-malate dehydrogenase activity | organic cyclic compound binding | NAD binding | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

brain development | oxidoreductase activity, acting on CH-OH group of donors | sulfur compound metabolic process | glycine metabolic process | cell differentiation | nervous system development | taurine metabolic process | generation of precursor metabolites and energy | neurogenesis | generation of neurons | cellular process | neuron development | serine family amino acid metabolic process | L-serine biosynthetic process | G1 to G0 transition | tissue development | cellular amino acid metabolic process | regulation of metabolic process | gliogenesis | xenobiotic metabolic process | epithelium development | cellular component organization | head development | response to stimulus | monocarboxylic acid metabolic process | cellular response to xenobiotic stimulus | cellular amino acid biosynthetic process | threonine metabolic process | electron transport chain | cellular biosynthetic process | embryo development | malate dehydrogenase activity | serine family amino acid biosynthetic process | regulation of neurotransmitter levels | L-serine metabolic process | phosphoglycerate dehydrogenase activity | system development | nitrogen compound metabolic process | multicellular organism development | electron transfer activity | regulation of gene expression | cell cycle | small molecule metabolic process | neurotransmitter metabolic process | biosynthetic process | neural tube development | glial cell differentiation | L-malate dehydrogenase activity | response to xenobiotic stimulus | gamma-aminobutyric acid metabolic process | chordate embryonic development | embryo development ending in birth or egg hatching | drug metabolic process | carboxylic acid metabolic process | neuron differentiation | anatomical structure development | glutamine metabolic process | cell projection organization | metabolic process | oxidation-reduction process | neuron projection development | organic substance metabolic process | animal organ development | glial cell development | cell development | organic acid metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | developmental process | tube development | central nervous system development | spinal cord development | cellular metabolic process | oxidoreductase activity | multicellular organismal process

GO Cellular Component

cell | cytoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular | myelin sheath