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QuickView for PHIP;jsessionid=E0DD44BDB8F15864C52FDBC3CBD2D2AF (gene)


Gene Symbol:
PHIP Homo sapiens Homo sapiens
Full name:
pleckstrin homology domain interacting protein
Synonyms:
BRWD2, DCAF14, WDR11, ndrp, PH-interacting protein, DDB1 and CUL4 associated factor 14, IRS-1 PH domain-binding protein, WD repeat-containing protein 11
Genomic Location:
Chr 6: 79706985-79844708
Description:
This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promot...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 6
6q14.1





GO Molecular Function

protein-containing complex binding | signaling receptor binding | lysine-acetylated histone binding | modification-dependent protein binding | protein binding | insulin receptor binding | histone binding

GO Biological Process

regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of programmed cell death | response to hormone | regulation of cell shape | negative regulation of cellular process | regulation of organelle organization | positive regulation of cellular biosynthetic process | cellular process | negative regulation of signaling | regulation of mitotic nuclear division | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | response to peptide hormone | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | cellular response to organonitrogen compound | cellular component organization | response to stimulus | regulation of cell proliferation | response to peptide | positive regulation of RNA biosynthetic process | regulation of nucleic acid-templated transcription | response to nitrogen compound | cellular response to hormone stimulus | regulation of signal transduction | positive regulation of organelle organization | cellular response to peptide hormone stimulus | cellular response to insulin stimulus | regulation of phosphorylation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | cellular response to peptide | insulin receptor signaling pathway | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | regulation of transcription by RNA polymerase II | negative regulation of extrinsic apoptotic signaling pathway | regulation of cellular protein metabolic process | regulation of apoptotic signaling pathway | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of mitotic cell cycle | response to organic substance | regulation of insulin-like growth factor receptor signaling pathway | response to insulin | cell surface receptor signaling pathway | regulation of RNA biosynthetic process | negative regulation of programmed cell death | regulation of phosphate metabolic process | cytoskeleton organization | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of developmental process | organelle organization | positive regulation of cell cycle process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | positive regulation of insulin-like growth factor receptor signaling pathway | regulation of cellular component organization | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular