QuickView for PIAS2 (gene)

Gene Symbol:

PIAS2 Homo sapiens

Full name:

protein inhibitor of activated STAT 2

Synonyms:

ARIP3, DIP, MIZ1, PIASX, SIZ2, ZMIZ4, E3 SUMO-protein ligase PIAS2, DAB2-interacting protein, androgen receptor-interacting protein 3, msx-interacting zinc finger protein, protein inhibitor of activated STAT X, zinc finger, MIZ-type containing 4

Genomic Location:

Chr 18: 42646058-42751464

Description:

This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein en...

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This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PTF1BETA_Q6 ,  AACTTT_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-137

Cytogenetic Map:

18q21.1

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