QuickView for PIAS3;jsessionid=CB20C22AEE13CF49BFA2D147599A34BC (gene)

Gene Symbol:

PIAS3 Homo sapiens

Full name:

protein inhibitor of activated STAT 3

Synonyms:

ZMIZ5, E3 SUMO-protein ligase PIAS3, protein inhibitor of activated STAT protein 3, zinc finger, MIZ-type containing 5

Genomic Location:

Chr 1: 144287345-144297903

Description:

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to ...

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This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  NFMUE1_Q6 ,  MAZ_Q6 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  ATGGYGGA_UNKNOWN ,  GCCATNTTG_YY1_Q6 ,  GGGAGGRR_MAZ_Q6 ,  ACATTCC_MIR1_MIR206 ,  GCACCTT_MIR18A_MIR18B ,  YY1_Q6 ,  GGATTA_PITX2_Q2 ,  TEF1_Q6 ,  SP1_Q4_01 ,  EGR_Q6 ,  GGGCGGR_SP1_Q6 ,  SP1_Q6 ,  WGGAATGY_TEF1_Q6 ,  YY1_02 ,  SMAD_Q6 ,  SP1_Q6_01 ,  FOXM1_01 ,  AACTTT_UNKNOWN ,  GGCAGTG_MIR3243P ,  SP1_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

1q21.1

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