QuickView for PIK3R3 (gene)

Gene Symbol:

PIK3R3 Homo sapiens

Full name:

phosphoinositide-3-kinase regulatory subunit 3

Synonyms:

p55, p55-GAMMA, p55PIK, phosphatidylinositol 3-kinase regulatory subunit gamma, PI3-kinase regulatory subunit gamma, PI3-kinase subunit p55-gamma, PI3K regulatory subunit gamma, phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma), phosphoinositide-3-kinase, regulatory subunit 3 (gamma), ptdIns-3-kinase regulatory subunit p55-gamma

Genomic Location:

Chr 1: 46278399-46370901

Description:

Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through w...

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Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  CMYB_01 ,  TTTGCAC_MIR19A_MIR19B ,  TGIF_01 ,  AGCYRWTTC_UNKNOWN ,  USF_Q6 ,  TTANTCA_UNKNOWN ,  TGGNNNNNNKCCAR_UNKNOWN ,  RSRFC4_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  E2F1_Q4_01 ,  SYATTGTG_UNKNOWN ,  SMAD3_Q6 ,  AAANWWTGC_UNKNOWN ,  RSRFC4_Q2 ,  AREB6_04 ,  E2F_01 ,  FAC1_01 ,  TTF1_Q6 ,  CTAWWWATA_RSRFC4_Q2 ,  TTAYRTAA_E4BP4_01 ,  GATA1_04 ,  E2F1_Q4 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  OSF2_Q6 ,  NFY_Q6_01 ,  GGCAGAC_MIR346 ,  CDX2_Q5 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  LHX3_01 ,  TST1_01 ,  NKX62_Q2 ,  HNF4_Q6 ,  ACCAAAG_MIR9 ,  NFY_01 ,  AHR_Q5 ,  S8_01 ,  NFY_Q6 ,  CTTTAAR_UNKNOWN ,  AAAGACA_MIR511 ,  POU1F1_Q6 ,  MEIS1_01 ,  PAX8_B ,  E2F_Q4_01 ,  OCT1_02 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  AP2REP_01 ,  GATA1_05 ,  MEF2_03 ,  WTTGKCTG_UNKNOWN ,  YTAATTAA_LHX3_01 ,  RGAGGAARY_PU1_Q6 ,  CREL_01 ,  E2F_Q2 ,  TGACAGNY_MEIS1_01 ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  YWATTWNNRGCT_UNKNOWN ,  ISRE_01 ,  CDC5_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  E2F_Q3_01 ,  STTTCRNTTT_IRF_Q6 ,  CTGRYYYNATT_UNKNOWN ,  HNF4_01_B ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-346 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

1p34.1

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