QuickView for PIM1 (gene)

Gene Symbol:

PIM1 Homo sapiens

Full name:

Pim-1 proto-oncogene, serine/threonine kinase

Synonyms:

PIM, serine/threonine-protein kinase pim-1, Oncogene PIM1, pim-1 kinase 44 kDa isoform, pim-1 oncogene (proviral integration site 1), proto-oncogene serine/threonine-protein kinase pim-1

Genomic Location:

Chr 6: 37245964-37251182

Description:

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and surviva...

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The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  OCT1_05 ,  GTGCCAT_MIR183 ,  MAZR_01 ,  TGANTCA_AP1_C ,  GATA1_03 ,  TTANTCA_UNKNOWN ,  P53_DECAMER_Q2 ,  TGANNYRGCA_TCF11MAFG_01 ,  HOXA4_Q2 ,  E2F1_Q4_01 ,  E2F4DP1_01 ,  HFH1_01 ,  XBP1_01 ,  TACTTGA_MIR26A_MIR26B ,  STAT6_01 ,  ZIC3_01 ,  CTTTGA_LEF1_Q2 ,  TGACCTY_ERR1_Q2 ,  GTACAGG_MIR486 ,  TCF4_Q5 ,  GGGAGGRR_MAZ_Q6 ,  CEBPB_01 ,  AP1_Q6_01 ,  LEF1_Q6 ,  PAX5_02 ,  E2F_Q6 ,  AP1_01 ,  HSF1_01 ,  TST1_01 ,  SP3_Q3 ,  E2F_Q4 ,  GTCTTCC_MIR7 ,  BACH2_01 ,  GGGCGGR_SP1_Q6 ,  STAT5A_03 ,  E2F1DP2_01 ,  HIF1_Q5 ,  SOX5_01 ,  ATACTGT_MIR144 ,  E2F_03 ,  AGGGCCA_MIR328 ,  E2F1DP1_01 ,  RORA1_01 ,  GTGCCTT_MIR506 ,  BACH1_01 ,  CCTGCTG_MIR214 ,  TTGTTT_FOXO4_01 ,  E2F1DP1RB_01 ,  E2F_02 ,  CTGAGCC_MIR24 ,  ZIC2_01 ,  CTGCAGY_UNKNOWN ,  E2F1_Q3 ,  RORA2_01 ,  E2F4DP2_01 ,  CTTTGT_LEF1_Q2 ,  KTGGYRSGAA_UNKNOWN ,  CACBINDINGPROTEIN_Q6 ,  SMAD_Q6 ,  BRN2_01 ,  E2F_Q3 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ERR1_Q2 ,  E2F_Q3_01 ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-486

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Cytogenetic Map:

6p21.2

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