QuickView for PIM2;jsessionid=6D3E08C58BAFEDA659A1F338CEF9EC38 (gene)
- Gene Symbol:
- PIM2
Homo sapiens - Full name:
- Pim-2 proto-oncogene, serine/threonine kinase
- Synonyms:
- serine/threonine-protein kinase pim-2, pim-2 oncogene, pim-2h, proto-oncogene Pim-2 (serine threonine kinase)
- Genomic Location:
- Chr X: 48655403-48661228
- Description:
-
This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
Xp11.23
GO Molecular Function
ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of macromolecule biosynthetic process | response to virus | protein stabilization | regulation of programmed cell death | regulation of autophagy | negative regulation of cellular process | male gamete generation | male meiotic nuclear division | positive regulation of cellular biosynthetic process | cellular process | multicellular organismal reproductive process | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | regulation of binding | gamete generation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | cellular component organization | response to stimulus | regulation of cell proliferation | protein serine/threonine kinase activity | programmed cell death | reproduction | cell cycle G1/S phase transition | regulation of macroautophagy | apoptotic mitochondrial changes | positive regulation of RNA biosynthetic process | protein modification process | mitochondrion organization | macromolecule modification | regulation of nucleic acid-templated transcription | apoptotic process | response to external biotic stimulus | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | regulation of protein stability | phosphorus metabolic process | regulation of gene expression | cell cycle | positive regulation of cellular metabolic process | protein autophosphorylation | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | negative regulation of binding | cell proliferation | phosphorylation | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | negative regulation of protein binding | regulation of cellular metabolic process | positive regulation of signal transduction | G1/S transition of mitotic cell cycle | regulation of RNA metabolic process | multicellular organism reproduction | protein metabolic process | regulation of intracellular signal transduction | mitotic cell cycle | nuclear division | metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | protein kinase activity | organic substance metabolic process | cell death | positive regulation of autophagy | positive regulation of macroautophagy | meiotic cell cycle | regulation of cell communication | negative regulation of molecular function | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | regulation of protein binding | cellular protein metabolic process | response to biotic stimulus | kinase activity | organelle organization | cellular protein modification process | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | sexual reproduction | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
