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QuickView for PLAT (gene)


Gene Symbol:
PLAT Homo sapiens Homo sapiens
Full name:
plasminogen activator, tissue type
Synonyms:
T-PA, TPA, tissue-type plasminogen activator, alteplase, plasminogen/activator kringle, reteplase, t-plasminogen activator
Genomic Location:
Chr 8: 42151393-42184351
Description:
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. Th...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 8
8p11.21





GO Molecular Function

signaling receptor binding | hydrolase activity | catalytic activity | serine hydrolase activity | phosphoprotein binding | protein binding | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | peptidase activity

GO Biological Process

cell motility | proteolysis | negative regulation of cellular process | protein processing | negative regulation of proteolysis | cellular process | localization | zymogen activation | hemostasis | response to hypoxia | regulation of proteolysis | negative regulation of cellular metabolic process | negative regulation of wound healing | regulation of cellular process | regulation of metabolic process | response to stimulus | response to stress | negative regulation of metabolic process | regulation of wound healing | protein modification process | macromolecule modification | blood coagulation | locomotion | response to oxygen levels | nitrogen compound metabolic process | cell migration | wound healing | platelet-derived growth factor receptor signaling pathway | regulation of blood coagulation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | regulation of cellular protein metabolic process | protein maturation | fibrinolysis | negative regulation of response to wounding | cell communication | regulation of cellular metabolic process | smooth muscle cell migration | regulation of protein metabolic process | coagulation | protein metabolic process | muscle cell migration | response to wounding | cell surface receptor signaling pathway | metabolic process | regulation of body fluid levels | organic substance metabolic process | negative regulation of cellular protein metabolic process | gene expression | serine-type endopeptidase activity | serine-type peptidase activity | negative regulation of protein metabolic process | regulation of response to wounding | signaling | endopeptidase activity | cellular protein metabolic process | cellular protein modification process | negative regulation of coagulation | negative regulation of blood coagulation | plasminogen activation | transmembrane receptor protein tyrosine kinase signaling pathway | cellular metabolic process | peptidase activity | signal transduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | extracellular matrix | cytoplasmic vesicle | cell | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | apical part of cell | secretory vesicle | endomembrane system | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | intracellular vesicle | cell surface | intracellular