QuickView for PLB1;jsessionid=176BDEE376F12E03E598CF656B88C902 (gene)

Gene Symbol:

PLB1 Homo sapiens

Full name:

phospholipase B1

Synonyms:

PLB, PLB/LIP, phospholipase B1, membrane-associated, lysophospholipase, phospholipase A2, phospholipase B/lipase

Genomic Location:

Chr 2: 28572486-28720117

Description:

This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracell...

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This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Cytogenetic Map:

2p23.2

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