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QuickView for PLD1 (gene)


Gene Symbol:
PLD1 Homo sapiens Homo sapiens
Full name:
phospholipase D1
Synonyms:
CVDD, phospholipase D1, choline phosphatase 1, phosphatidylcholine-hydrolyzing phospholipase D1, phospholipase D1, phosphatidylcholine-specific
Genomic Location:
Chr 3: 172801339-172938566
Description:
This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory propertie...
Orthologs:
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3
3q26.31





GO Molecular Function

N-acylphosphatidylethanolamine-specific phospholipase D activity | phospholipase activity | lipid binding | hydrolase activity | phospholipid binding | catalytic activity | anion binding | hydrolase activity, acting on ester bonds | phospholipase D activity | ion binding | lipase activity | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | phosphatidylinositol binding

GO Biological Process

exocytosis | cell motility | neutrophil activation | intracellular signal transduction | establishment of localization | phospholipid metabolic process | cellular process | secretion | organic substance catabolic process | leukocyte degranulation | localization | regulation of cellular process | leukocyte activation | catabolic process | small GTPase mediated signal transduction | cellular lipid metabolic process | response to stimulus | neutrophil degranulation | leukocyte activation involved in immune response | secretion by cell | cellular biosynthetic process | locomotion | regulation of cell projection assembly | phosphatidic acid metabolic process | phosphorus metabolic process | leukocyte mediated immunity | lipid metabolic process | organophosphate metabolic process | phospholipid biosynthetic process | vesicle-mediated transport | biosynthetic process | regulated exocytosis | lipid biosynthetic process | inositol lipid-mediated signaling | phosphate-containing compound metabolic process | cell communication | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | glycerolipid metabolic process | regulation of microvillus assembly | glycerophospholipid biosynthetic process | metabolic process | immune response | lipid catabolic process | organic substance metabolic process | cell activation | signaling | glycerophospholipid metabolic process | Ras protein signal transduction | neutrophil mediated immunity | regulation of cell projection organization | immune system process | phosphatidic acid biosynthetic process | cellular metabolic process | chemotaxis | regulation of cellular component organization | signal transduction

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | late endosome | apical plasma membrane | organelle membrane | tertiary granule | cytoplasmic vesicle | cell | late endosome membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | secretory granule membrane | apical part of cell | endosome membrane | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | secretory vesicle | endomembrane system | endoplasmic reticulum membrane | plasma membrane | vacuole | vesicle | perinuclear region of cytoplasm | specific granule | lytic vacuole | Golgi membrane | endosome | membrane-bounded organelle | organelle | vesicle membrane | lysosome | cell periphery | tertiary granule membrane | intracellular vesicle | endocytic vesicle | intracellular | specific granule membrane | lysosomal membrane | membrane | cytoplasmic vesicle membrane | vacuolar membrane