QuickView for PLD3 (gene)

Gene Symbol:

PLD3 Homo sapiens

Full name:

phospholipase D family member 3

Synonyms:

AD19, HU-K4, HUK4, SCA46, phospholipase D3, choline phosphatase 3, hindIII K4L homolog, phosphatidylcholine-hydrolyzing phospholipase D3

Genomic Location:

Chr 19: 45546447-45576230

Description:

This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated wi...

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This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATGCTGG_MIR338 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  RGAGGAARY_PU1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

19q13.2

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