QuickView for PLOD1 (gene)

Gene Symbol:

PLOD1 Homo sapiens

Full name:

procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

Synonyms:

EDS6, EDSKCL1, LH, LH1, LLH, PLOD, procollagen-lysine,2-oxoglutarate 5-dioxygenase 1, lysine hydroxylase, lysyl hydroxlase 1, procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1

Genomic Location:

Chr 1: 11917333-11958181

Description:

Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stabi...

View Full Description

Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  RGAANNTTC_HSF1_01 ,  GCTCTTG_MIR335 ,  HSF_Q6 ,  HSF2_01 ,  CCCNNNNNNAAGWT_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-34

Cytogenetic Map:

1p36.22

search → result