QuickView for PLOD3 (gene)

Gene Symbol:

PLOD3 Homo sapiens

Full name:

procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

Synonyms:

LH3, procollagen-lysine,2-oxoglutarate 5-dioxygenase 3, lysine hydroxylase 3, lysyl hydroxlase 3, lysyl hydroxylase 3

Genomic Location:

Chr 7: 100635978-100647731

Description:

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thu...

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The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NGFIC_01 ,  TGCGCANK_UNKNOWN ,  NRF1_Q6 ,  GTGCCTT_MIR506 ,  YGCGYRCGC_UNKNOWN ,  NRF2_01 ,  EGR1_01 ,  RCGCANGCGY_NRF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-182

miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes

Cytogenetic Map:

7q22.1

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