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QuickView for PMEL (gene)


Gene Symbol:
PMEL Homo sapiens Homo sapiens
Full name:
premelanosome protein
Synonyms:
D12S53E, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100, melanocyte protein PMEL, melanocyte protein Pmel 17, melanocyte protein mel 17, melanocytes lineage-specific antigen GP100, melanoma-associated ME20 antigen, melanosomal matrix protein17, silver locus protein homolog, silver, mouse, homolog of
Genomic Location:
Chr 12: 54634156-54646093
Description:
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition f...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 12
12q13.2





GO Molecular Function

identical protein binding | protein binding

GO Biological Process

phenol-containing compound metabolic process | melanosome organization | melanin metabolic process | cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | cellular biosynthetic process | organic hydroxy compound metabolic process | pigment granule organization | melanin biosynthetic process | pigment biosynthetic process | pigmentation | biosynthetic process | aromatic compound biosynthetic process | metabolic process | organic substance metabolic process | pigment metabolic process | vesicle organization | organelle organization | cellular pigmentation | cellular metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | late endosome | organelle membrane | cytoplasmic vesicle | cell | late endosome membrane | multivesicular body | intrinsic component of membrane | cytoplasm | multivesicular body membrane | intracellular organelle | endoplasmic reticulum | melanosome | endosome membrane | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | plasma membrane | vesicle | integral component of plasma membrane | endosome | extracellular region | membrane-bounded organelle | organelle | cell periphery | intracellular vesicle | intracellular | membrane | intrinsic component of plasma membrane