Correlation Engine 2.0
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QuickView for POLB (gene)

Gene Symbol:
POLB Homo sapiens Homo sapiens
Full name:
DNA polymerase beta
DNA polymerase beta, DNA pol beta, DNA polymerase beta subunit, polymerase (DNA directed), beta, polymerase (DNA) beta
Genomic Location:
Chr 8: 42315187-42348470
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has...
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Canis lupus familiaris Danio rerio Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 8

GO Molecular Function

DNA-(apurinic or apyrimidinic site) endonuclease activity | cation binding | DNA-directed DNA polymerase activity | enzyme binding | nucleic acid binding | DNA polymerase activity | lyase activity | nucleotidyltransferase activity | catalytic activity | cytoskeletal protein binding | DNA binding | damaged DNA binding | ion binding | organic cyclic compound binding | protein binding | transferase activity, transferring phosphorus-containing groups | transferase activity | microtubule binding | tubulin binding | metal ion binding | heterocyclic compound binding

GO Biological Process

protein modification by small protein removal | response to radiation | somatic hypermutation of immunoglobulin genes | intracellular signal transduction | proteolysis | base-excision repair, base-free sugar-phosphate removal | neuron death | defense response | intrinsic apoptotic signaling pathway in response to DNA damage | response to drug | response to antibiotic | salivary gland morphogenesis | cellular process | DNA-directed DNA polymerase activity | immune system development | intrinsic apoptotic signaling pathway | somatic diversification of immune receptors via somatic mutation | regulation of cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | protein deubiquitination | response to stimulus | gland morphogenesis | response to stress | cellular nitrogen compound biosynthetic process | DNA polymerase activity | programmed cell death | response to alcohol | cellular nitrogen compound metabolic process | protein modification process | pyrimidine dimer repair | cellular biosynthetic process | DNA recombination | macromolecule modification | DNA repair | response to ethanol | apoptotic process | polynucleotide dephosphorylation | system development | response to oxygen levels | nitrogen compound metabolic process | multicellular organism development | phosphorus metabolic process | cellular response to DNA damage stimulus | spleen development | somatic recombination of immunoglobulin gene segments | DNA biosynthetic process | cellular response to stress | animal organ morphogenesis | neuron apoptotic process | homeostasis of number of cells | V(D)J recombination | biosynthetic process | aromatic compound biosynthetic process | response to hyperoxia | response to toxic substance | response to gamma radiation | phosphate-containing compound metabolic process | cell communication | inflammatory response | base-excision repair | homeostatic process | DNA ligation involved in DNA repair | nucleotide-excision repair, DNA gap filling | apoptotic signaling pathway | lymph node development | protein metabolic process | response to organic substance | gland development | DNA metabolic process | anatomical structure development | metabolic process | nucleotide-excision repair | immunoglobulin production | somatic diversification of immunoglobulins | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | base-excision repair, gap-filling | animal organ development | protein modification by small protein conjugation or removal | dephosphorylation | signaling | DNA ligation | cellular protein metabolic process | anatomical structure morphogenesis | somatic cell DNA recombination | cellular macromolecule biosynthetic process | developmental process | base-excision repair, DNA ligation | cellular protein modification process | immunoglobulin heavy chain V-D-J recombination | heterocycle metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | exocrine system development | salivary gland development | DNA replication | aging | response to ionizing radiation | immunoglobulin V(D)J recombination | signal transduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

supramolecular fiber | intracellular membrane-bounded organelle | cell | nuclear lumen | microtubule | cytoplasm | spindle | intracellular organelle | protein-containing complex | nucleoplasm | microtubule cytoskeleton | spindle microtubule | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytoskeleton | intracellular | supramolecular complex