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QuickView for PPARA (gene)


Gene Symbol:
PPARA Homo sapiens Homo sapiens
Full name:
peroxisome proliferator activated receptor alpha
Synonyms:
NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator-activated receptor alpha, PPAR-alpha, nuclear receptor subfamily 1 group C member 1, peroxisome proliferative activated receptor, alpha, peroxisome proliferator-activated nuclear receptor alpha variant 3
Genomic Location:
Chr 22: 44925163-45018317
Description:
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The act...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 22
22q13.31





GO Molecular Function

sequence-specific DNA binding | fatty acid binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | nuclear receptor activity | cation binding | repressing transcription factor binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | transcription factor activity, RNA polymerase II transcription factor binding | proximal promoter sequence-specific DNA binding | carboxylic acid binding | enzyme binding | nucleic acid binding | protein-containing complex binding | lipid binding | transcription coactivator binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor activity | protein domain specific binding | NFAT protein binding | anion binding | RNA polymerase II repressing transcription factor binding | RNA polymerase II regulatory region DNA binding | ubiquitin conjugating enzyme binding | DNA binding | MDM2/MDM4 family protein binding | signaling receptor activity | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ion binding | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | transcriptional activator activity, RNA polymerase II transcription factor binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | nuclear receptor transcription coactivator activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ubiquitin-like protein conjugating enzyme binding | transition metal ion binding | drug binding | phosphatase binding | transcription cofactor binding | transcription coregulator activity | organic acid binding | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter | negative regulation of phosphorylation | DNA-templated transcription, initiation | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | response to nutrient levels | negative regulation of sequestering of triglyceride | regulation of localization | regulation of carbohydrate metabolic process | lipid transport | positive regulation of lipid catabolic process | establishment of localization | response to hormone | negative regulation of neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of fatty acid oxidation | negative regulation of leukocyte cell-cell adhesion | negative regulation of RNA biosynthetic process | cell differentiation | response to drug | regulation of lipid transport | hormone-mediated signaling pathway | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | negative regulation of inflammatory response | nuclear receptor activity | monocarboxylic acid transport | circadian regulation of gene expression | localization | regulation of glycolytic process | odontogenesis | anion transport | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | macromolecule localization | response to hypoxia | tooth mineralization | positive regulation of nitrogen compound metabolic process | regulation of appetite | negative regulation of cholesterol storage | transcription factor activity, RNA polymerase II transcription factor binding | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of binding | regulation of cell differentiation | negative regulation of receptor biosynthetic process | regulation of cellular process | cellular response to lipid | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | negative regulation of appetite | cellular aromatic compound metabolic process | negative regulation of nucleotide metabolic process | behavioral response to nicotine | cellular lipid metabolic process | response to stimulus | monocarboxylic acid metabolic process | regulation of macrophage derived foam cell differentiation | negative regulation of cell adhesion | response to stress | cellular nitrogen compound biosynthetic process | response to peptide | circadian rhythm | regulation of transcription regulatory region DNA binding | rhythmic process | cellular nitrogen compound metabolic process | regulation of DNA binding | cellular response to organic cyclic compound | blood circulation | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | regulation of cell adhesion | cellular biosynthetic process | regulation of lipid storage | negative regulation of blood pressure | regulation of nucleic acid-templated transcription | response to nitrogen compound | cellular response to hormone stimulus | response to nicotine | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of fatty acid beta-oxidation | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of ATP metabolic process | lipid metabolic process | regulation of phosphorylation | positive regulation of gluconeogenesis | regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter | wound healing | regulation of gene expression | fatty acid transport | organic substance transport | response to lipid | regulation of response to food | regulation of blood pressure | positive regulation of cellular metabolic process | negative regulation of lipid storage | animal organ morphogenesis | regulation of pri-miRNA transcription by RNA polymerase II | amelogenesis | regulation of nitrogen compound metabolic process | small molecule metabolic process | negative regulation of DNA binding | regulation of transcription by RNA polymerase II | organic acid transport | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of binding | regulation of fatty acid metabolic process | biosynthetic process | aromatic compound biosynthetic process | negative regulation of transcription regulatory region DNA binding | organic anion transport | epidermis development | response to toxic substance | regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter | negative regulation of cell-cell adhesion | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of lipid catabolic process | lipoprotein metabolic process | odontogenesis of dentin-containing tooth | heart development | regulation of sequestering of triglyceride | transcription coactivator activity | regulation of RNA metabolic process | carboxylic acid metabolic process | transcriptional activator activity, RNA polymerase II transcription factor binding | regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter | negative regulation of carbohydrate metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | negative regulation of response to food | response to organic substance | positive regulation of fatty acid beta-oxidation | response to wounding | positive regulation of fatty acid metabolic process | response to insulin | anatomical structure development | regulation of glucose metabolic process | metabolic process | lipid localization | regulation of receptor biosynthetic process | positive regulation of glucose metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nuclear receptor transcription coactivator activity | behavior | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of glycolytic process | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | regulation of fatty acid oxidation | negative regulation of ATP biosynthetic process | regulation of ATP metabolic process | regulation of phosphate metabolic process | biomineral tissue development | cellular response to steroid hormone stimulus | fatty acid metabolic process | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | intracellular receptor signaling pathway | anatomical structure formation involved in morphogenesis | adult behavior | positive regulation of carbohydrate metabolic process | negative regulation of macrophage derived foam cell differentiation | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | organic acid metabolic process | carboxylic acid transport | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of circadian rhythm | regulation of cellular ketone metabolic process | regulation of developmental process | developmental process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of gluconeogenesis | regulation of generation of precursor metabolites and energy | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | ion transport | cellular metabolic process | cellular response to organic substance | enamel mineralization | regulation of cell death | response to steroid hormone | negative regulation of cell death | circulatory system development | regulation of inflammatory response | negative regulation of pri-miRNA transcription by RNA polymerase II | negative regulation of cell differentiation | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

nuclear transcription factor complex | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular