QuickView for PPARGC1A;jsessionid=FA902B44B6859B06376DB8A60F248A89 (gene)

Gene Symbol:

PPARGC1A Homo sapiens

Full name:

PPARG coactivator 1 alpha

Synonyms:

LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A, PPARGC1, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, L-PGC-1alpha, PGC-1-alpha, PPAR gamma coactivator variant form, PPARGC-1-alpha, PPARgamma coactivator 1alpha, ligand effect modulator-6, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT

Genomic Location:

Chr 4: 23402742-23500798

Description:

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CRE...

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The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  POU6F1_01 ,  IRF1_01 ,  RTAAACA_FREAC2_01 ,  HNF4ALPHA_Q6 ,  ACTGTAG_MIR139 ,  STAT4_01 ,  TGANTCA_AP1_C ,  PPARG_01 ,  MYOD_01 ,  TCANNTGAY_SREBP1_01 ,  CREBP1CJUN_01 ,  FOXJ2_02 ,  TGGNNNNNNKCCAR_UNKNOWN ,  AAAGGGA_MIR204_MIR211 ,  HOXA4_Q2 ,  PPARA_01 ,  GATA_Q6 ,  TTTTGAG_MIR373 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  GCANCTGNY_MYOD_Q6 ,  AAAYWAACM_HFH4_01 ,  AAANWWTGC_UNKNOWN ,  CTATGCA_MIR153 ,  EVI1_04 ,  TTTGTAG_MIR520D ,  MEF2_04 ,  AMEF2_Q6 ,  GATAAGR_GATA_C ,  CTTTGA_LEF1_Q2 ,  IRF1_Q6 ,  COUP_01 ,  AAGCAAT_MIR137 ,  AATGGAG_MIR136 ,  CTAWWWATA_RSRFC4_Q2 ,  CREB_Q4 ,  TGACCTY_ERR1_Q2 ,  WHN_B ,  CREB_Q3 ,  TAAWWATAG_RSRFC4_Q2 ,  TCF4_Q5 ,  HNF4_DR1_Q3 ,  MEF2_02 ,  TGAYRTCA_ATF3_Q6 ,  STAT_Q6 ,  ATF_B ,  HNF4_01 ,  CREBP1_Q2 ,  TATAAA_TATA_01 ,  AR_Q6 ,  EVI1_03 ,  TGTATGA_MIR4853P ,  ATCATGA_MIR433 ,  DBP_Q6 ,  TAATGTG_MIR323 ,  TITF1_Q3 ,  GTGACGY_E4F1_Q6 ,  CCTGTGA_MIR513 ,  ATF_01 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  DR1_Q3 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  ATACCTC_MIR202 ,  CACCAGC_MIR138 ,  CAGCTTT_MIR320 ,  EVI1_02 ,  EVI1_05 ,  MYOD_Q6 ,  CREB_02 ,  HNF3B_01 ,  ATF3_Q6 ,  ATGTTAA_MIR302C ,  AREB6_01 ,  GACAATC_MIR219 ,  ATGTTTC_MIR494 ,  LMO2COM_02 ,  GATA6_01 ,  E4F1_Q6 ,  ACTAYRNNNCCCR_UNKNOWN ,  NKX61_01 ,  RAAGNYNNCTTY_UNKNOWN ,  TAATAAT_MIR126 ,  CTTTAAR_UNKNOWN ,  AAAGACA_MIR511 ,  GCCNNNWTAAR_UNKNOWN ,  HFH8_01 ,  PTF1BETA_Q6 ,  AR_Q2 ,  GFI1_01 ,  AATGTGA_MIR23A_MIR23B ,  OCT1_02 ,  TTGTTT_FOXO4_01 ,  YTAAYNGCT_UNKNOWN ,  CHOP_01 ,  GATA4_Q3 ,  STAT5A_04 ,  MEF2_03 ,  CREB_Q2 ,  COUP_DR1_Q6 ,  TGACGTCA_ATF3_Q6 ,  TGATTTRY_GFI1_01 ,  CAGCCTC_MIR4855P ,  TGACAGNY_MEIS1_01 ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  TBP_01 ,  ISRE_01 ,  CDC5_01 ,  FOXM1_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  PPAR_DR1_Q2 ,  USF_02 ,  HNF1_Q6 ,  CREB_Q2_01 ,  CEBPGAMMA_Q6 ,  CAATGCA_MIR33 ,  STTTCRNTTT_IRF_Q6 ,  CREB_01 ,  HNF4_01_B ,  TATTATA_MIR374 ,  ACACTGG_MIR199A_MIR199B ,  AAGCACA_MIR218 ,  ATGTAGC_MIR221_MIR222 ,  TCF11MAFG_01 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-136 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

4p15.2

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