QuickView for PPM1D (gene)

Gene Symbol:

PPM1D Homo sapiens

Full name:

protein phosphatase, Mg2+/Mn2+ dependent 1D

Synonyms:

IDDGIP, PP2C-DELTA, WIP1, protein phosphatase 1D, protein phosphatase 1D magnesium-dependent, delta isoform, protein phosphatase 2C delta isoform, protein phosphatase Wip1, wild-type p53-induced phosphatase 1

Genomic Location:

Chr 17: 56032336-56096818

Description:

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP5...

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The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  ATGCAGT_MIR217 ,  PBX1_02 ,  RTAAACA_FREAC2_01 ,  FOX_Q2 ,  P53_DECAMER_Q2 ,  GATA_C ,  E2F4DP1_01 ,  ZF5_01 ,  HFH1_01 ,  CTATGCA_MIR153 ,  TTTGTAG_MIR520D ,  E2F_Q6_01 ,  IRF1_Q6 ,  RGAANNTTC_HSF1_01 ,  E2F_Q6 ,  E2F1_Q6_01 ,  EGR_Q6 ,  E2F_Q4 ,  NF1_Q6 ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  E2F1DP2_01 ,  TGCCAAR_NF1_Q6 ,  MEIS1_01 ,  NF1_Q6_01 ,  SOX5_01 ,  E2F_03 ,  E2F1DP1_01 ,  E2F_Q4_01 ,  RNGTGGGC_UNKNOWN ,  FREAC2_01 ,  TTGTTT_FOXO4_01 ,  E2F1DP1RB_01 ,  E2F_02 ,  E2F1_Q3 ,  TGACAGNY_MEIS1_01 ,  E2F4DP2_01 ,  RCGCANGCGY_NRF1_Q6 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  SRY_02 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  GGARNTKYCCA_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

17q23.2

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