QuickView for PPM1E (gene)

Gene Symbol:

PPM1E Homo sapiens

Full name:

protein phosphatase, Mg2+/Mn2+ dependent 1E

Synonyms:

CaMKP-N, POPX1, PP2CH, caMKN, protein phosphatase 1E, ca(2+)/calmodulin-dependent protein kinase phosphatase N, caMKP-nucleus, nuclear calmodulin-dependent protein kinase phosphatase, partner of PIX 1, partner of PIX-alpha, partner of PIXA, protein phosphatase 1E (PP2C domain containing)

Genomic Location:

Chr 17: 54188231-54417319

Description:

This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. ...

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This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  CMYB_01 ,  OCT1_05 ,  GTGCCAT_MIR183 ,  CCCAGAG_MIR326 ,  HOXA4_Q2 ,  AP3_Q6 ,  GATA_Q6 ,  TTTTGAG_MIR373 ,  GATA_C ,  YTATTTTNR_MEF2_02 ,  TTTGTAG_MIR520D ,  CAGTGTT_MIR141_MIR200A ,  ARP1_01 ,  AP2GAMMA_01 ,  GATAAGR_GATA_C ,  NKX22_01 ,  AAGCAAT_MIR137 ,  AP2ALPHA_01 ,  MAF_Q6 ,  TGACCTY_ERR1_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  GGGAGGRR_MAZ_Q6 ,  RYTGCNWTGGNR_UNKNOWN ,  CCTGTGA_MIR513 ,  CEBP_01 ,  RFX1_02 ,  TATA_C ,  AP2_Q6_01 ,  CCAWYNNGAAR_UNKNOWN ,  TGCTGAY_UNKNOWN ,  LMO2COM_02 ,  GATA6_01 ,  HIF1_Q5 ,  AAGWWRNYGGC_UNKNOWN ,  NKX61_01 ,  NKX25_02 ,  CTTTAAR_UNKNOWN ,  AP2_Q3 ,  TGTYNNNNNRGCARM_UNKNOWN ,  YCATTAA_UNKNOWN ,  RNGTGGGC_UNKNOWN ,  TTGCCAA_MIR182 ,  AP2_Q6 ,  CEBP_Q3 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  YGCGYRCGC_UNKNOWN ,  CART1_01 ,  GTCNYYATGR_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  YTAATTAA_LHX3_01 ,  GTGGTGA_MIR197 ,  SREBP_Q3 ,  ATAACCT_MIR154 ,  TGCTTTG_MIR330 ,  ER_Q6_02 ,  CCATCCA_MIR432 ,  ER_Q6_01 ,  CAGCTG_AP4_Q5 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ERR1_Q2 ,  TCATCTC_MIR143 ,  HIF1_Q3 ,  ACCATTT_MIR522 ,  GTTRYCATRR_UNKNOWN ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

17q22

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