QuickView for PPP1R8;jsessionid=DE4E0C148F45692259CEDA63456D514B (gene)

Gene Symbol:

PPP1R8 Homo sapiens

Full name:

protein phosphatase 1 regulatory subunit 8

Synonyms:

ARD-1, ARD1, NIPP-1, NIPP1, PRO2047, nuclear inhibitor of protein phosphatase 1, RNase E, activator of RNA decay, nuclear inhibitor of protein phosphatase-1 alpha, nuclear inhibitor of protein phosphatase-1 beta, nuclear subunit of PP-1, protein phosphatase 1, regulatory (inhibitor) subunit 8

Genomic Location:

Chr 1: 28029880-28050770

Description:

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to...

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This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMTTTTGT_UNKNOWN ,  TGANTCA_AP1_C ,  E2F1_Q4_01 ,  ATTACAT_MIR3803P ,  WGTTNNNNNAAA_UNKNOWN ,  TAGCTTT_MIR9 ,  ZIC3_01 ,  E2F1_Q4 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  TCCCRNNRTGC_UNKNOWN ,  E2F_Q6 ,  E2F1_Q6_01 ,  E2F_Q4 ,  E2F_Q4_01 ,  E2F1DP1RB_01 ,  E2F_Q3 ,  E2F_Q3_01 ,  CEBPGAMMA_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-136

Cytogenetic Map:

1p35.3

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