QuickView for PPP2CA (gene)

Gene Symbol:

PPP2CA Homo sapiens

Full name:

protein phosphatase 2 catalytic subunit alpha

Synonyms:

PP2Ac, PP2CA, PP2Calpha, RP-C, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform, protein phosphatase 2, catalytic subunit, alpha isozyme, replication protein C, serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform

Genomic Location:

Chr 5: 133560047-133589849

Description:

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a va...

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This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ACTGTAG_MIR139 ,  GTGCCAT_MIR183 ,  AP1_C ,  TGANTCA_AP1_C ,  TGANNYRGCA_TCF11MAFG_01 ,  YRTCANNRCGC_UNKNOWN ,  GAGACTG_MIR452 ,  TTTGTAG_MIR520D ,  CAGTGTT_MIR141_MIR200A ,  AP1_Q6 ,  GCCATNTTG_YY1_Q6 ,  TGACCTY_ERR1_Q2 ,  TGAYRTCA_ATF3_Q6 ,  NFE2_01 ,  AP1_Q6_01 ,  GGGYGTGNY_UNKNOWN ,  CEBP_01 ,  AP1_01 ,  AP1FJ_Q2 ,  BACH2_01 ,  TGCTGAY_UNKNOWN ,  AP1_Q2_01 ,  OCT1_03 ,  ACTGCAG_MIR173P ,  NF1_Q6_01 ,  RORA1_01 ,  BACH1_01 ,  TAATTA_CHX10_01 ,  AACATTC_MIR4093P ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  YY1_02 ,  RORA2_01 ,  AP1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AP1_Q4_01 ,  TCF11MAFG_01 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-495

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Cytogenetic Map:

5q31.1

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