QuickView for PRC1 (gene)

Gene Symbol:

PRC1 Homo sapiens

Full name:

protein regulator of cytokinesis 1

Synonyms:

ASE1, protein regulator of cytokinesis 1, anaphase spindle elongation 1 homolog, protein regulating cytokinesis 1

Genomic Location:

Chr 15: 89310272-89338808

Description:

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mi...

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This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  CTTTGCA_MIR527 ,  GGGCGGR_SP1_Q6 ,  AAGCACT_MIR520F

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-19

miRNA binding sites
(Source: miRecords):

hsa-miR-373 Targeted Genes

Cytogenetic Map:

15q26.1

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