QuickView for PRDM16 (gene)

Gene Symbol:

PRDM16 Homo sapiens

Full name:

PR/SET domain 16

Synonyms:

CMD1LL, KMT8F, LVNC8, MEL1, PFM13, PR domain zinc finger protein 16, MDS1/EVI1-like gene 1, PR domain 16, PR domain containing 16, transcription factor MEL1

Genomic Location:

Chr 1: 2975604-3345045

Description:

The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contai...

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The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

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Orthologs:

Mus musculus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Rattus norvegicus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_Q6_01 ,  IRF1_01 ,  TFIIA_Q6 ,  MAZ_Q6 ,  PPARA_01 ,  ZF5_01 ,  AAANWWTGC_UNKNOWN ,  WGTTNNNNNAAA_UNKNOWN ,  AP2GAMMA_01 ,  COUP_01 ,  AP2ALPHA_01 ,  TGACCTY_ERR1_Q2 ,  HNF4_DR1_Q3 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  HNF4_01 ,  CEBP_Q2 ,  CEBPB_01 ,  CACCCBINDINGFACTOR_Q6 ,  TEF1_Q6 ,  CAGGTG_E12_Q6 ,  DR1_Q3 ,  TATA_C ,  AP2_Q6_01 ,  GGGCGGR_SP1_Q6 ,  E2F1_Q3_01 ,  IRF_Q6 ,  CTTTAAR_UNKNOWN ,  AP2_Q3 ,  IRF7_01 ,  COUP_DR1_Q6 ,  E2F_Q2 ,  ICSBP_Q6 ,  ISRE_01 ,  AACTTT_UNKNOWN ,  PPAR_DR1_Q2 ,  HNF4_01_B ,  IRF2_01 ,  ETF_Q6 ,  MYB_Q3

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Cytogenetic Map:

1p36.32

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