QuickView for PRDX5 (gene)

Gene Symbol:

PRDX5 Homo sapiens

Full name:

peroxiredoxin 5

Synonyms:

ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, SBBI10, prx-V, peroxiredoxin-5, mitochondrial, Alu co-repressor 1, TPx type VI, antioxidant enzyme B166, epididymis secretory protein Li 55, liver tissue 2D-page spot 71B, peroxiredoxin V, peroxisomal antioxidant enzyme, thioredoxin peroxidase PMP20, thioredoxin reductase

Genomic Location:

Chr 11: 63842145-63845859

Description:

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription s...

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This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  HNF3ALPHA_Q6 ,  GATA1_01 ,  ZIC1_01 ,  FOX_Q2 ,  YTATTTTNR_MEF2_02 ,  TAAWWATAG_RSRFC4_Q2 ,  GGGAGGRR_MAZ_Q6 ,  P53_02 ,  CDX2_Q5 ,  TST1_01 ,  NKX62_Q2 ,  HNF3_Q6 ,  MGGAAGTG_GABP_B ,  POU1F1_Q6 ,  YCATTAA_UNKNOWN ,  SCGGAAGY_ELK1_02 ,  NRF2_01 ,  ICSBP_Q6 ,  FOXM1_01 ,  HNF6_Q6 ,  IRF2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-25

Cytogenetic Map:

11q13.1

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