QuickView for PRIMPOL;jsessionid=42CC494BDBE760F795E46B43F892952F (gene)

Gene Symbol:

PRIMPOL Homo sapiens

Full name:

primase and DNA directed polymerase

Synonyms:

CCDC111, MYP22, Primpol1, DNA-directed primase/polymerase protein, coiled-coil domain-containing protein 111, hPrimpol1

Genomic Location:

Chr 4: 185807896-185853106

Description:

This gene encodes a DNA primase-polymerase that belongs to a superfamily of archaeao-eukaryotic primases. Members of this family have primase activity, catalyzing the synthesis of short RNA primers that serve as starting points for DNA synthesis, as well as DNA polymerase activity. The encoded protein facilitates DNA damage tolerance by mediating u...

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This gene encodes a DNA primase-polymerase that belongs to a superfamily of archaeao-eukaryotic primases. Members of this family have primase activity, catalyzing the synthesis of short RNA primers that serve as starting points for DNA synthesis, as well as DNA polymerase activity. The encoded protein facilitates DNA damage tolerance by mediating uninterrupted fork progression after UV irradiation and reinitiating DNA synthesis. An allelic variant in this gene is associated with myopia 22. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

miRNA binding sites
(Source: miRecords):

hsa-miR-15a/hsa-miR-16 Targeted Genes

Cytogenetic Map:

4q35.1

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