QuickView for PRKAA2;jsessionid=22F855C2BFDD7F9C4867264A606F1DEF (gene)

Gene Symbol:

PRKAA2 Homo sapiens

Full name:

protein kinase AMP-activated catalytic subunit alpha 2

Synonyms:

AMPK, AMPK2, AMPKa2, PRKAA, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase, catalytic alpha-2 chain, ACACA kinase, AMP-activated protein kinase alpha-2 subunit variant 2, AMP-activated protein kinase alpha-2 subunit variant 3, AMPK alpha 2, AMPK subunit alpha-2, AMPK-alpha-2 chain, HMGCR kinase, acetyl-CoA carboxylase kinase, hydroxymethylglutaryl-CoA reductase kinase, protein kinase, AMP-activated, alpha 2 catalytic subunit

Genomic Location:

Chr 1: 56883578-56953596

Description:

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated...

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The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

YTATTTTNR_MEF2_02 ,  E4BP4_01 ,  TTAYRTAA_E4BP4_01 ,  TATAAA_TATA_01 ,  TEF1_Q6 ,  TGCTGAY_UNKNOWN ,  HLF_01 ,  TBP_01 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  ER_Q6 ,  SF1_Q6 ,  MEF2_Q6_01

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Cytogenetic Map:

1p32.2

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