QuickView for PRKAB1 (gene)

Gene Symbol:

PRKAB1 Homo sapiens

Full name:

protein kinase AMP-activated non-catalytic subunit beta 1

Synonyms:

AMPK, HAMPKb, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase beta-1 subunit, AMP-activated protein kinase beta subunit, AMPK beta -1 chain, AMPK beta 1, AMPK subunit beta-1, AMPKb, protein kinase, AMP-activated, beta 1 non-catalytic subunit, protein kinase, AMP-activated, noncatalytic, beta-1

Genomic Location:

Chr 12: 118590144-118603812

Description:

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activate...

View Full Description

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GABP_B ,  HOXA4_Q2 ,  CCTGAGT_MIR510 ,  TGACCTY_ERR1_Q2 ,  CTTTGTA_MIR524 ,  LHX3_01 ,  GGAANCGGAANY_UNKNOWN ,  S8_01 ,  NKX25_02 ,  HSF_Q6 ,  YCATTAA_UNKNOWN ,  NCX_01 ,  CHX10_01 ,  ELK1_01 ,  TAATTA_CHX10_01 ,  SCGGAAGY_ELK1_02 ,  YTAATTAA_LHX3_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-137

Cytogenetic Map:

12q24.23

search → result