QuickView for PRKCA;jsessionid=22F855C2BFDD7F9C4867264A606F1DEF (gene)

Gene Symbol:

PRKCA Homo sapiens

Full name:

protein kinase C alpha

Synonyms:

AAG6, PKC-alpha, PKCA, PRKACA, protein kinase C alpha type, PKC-A, aging-associated gene 6

Genomic Location:

Chr 17: 61729388-62237324

Description:

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for ph...

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Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTATTAT_MIR3693P ,  GTGCCAT_MIR183 ,  CTTTGCA_MIR527 ,  CATTTCA_MIR203 ,  CAAGGAT_MIR362

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-362

Cytogenetic Map:

17q24.2

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