QuickView for PRKDC;jsessionid=8700D2B5A74F4BB15F1549BA47D3A3B9 (gene)
- Gene Symbol:
- PRKDC
Homo sapiens - Full name:
- protein kinase, DNA-activated, catalytic polypeptide
- Synonyms:
- DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, IMD26, XRCC7, p350, DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, hyper-radiosensitivity of murine scid mutation, complementing 1, p460
- Genomic Location:
- Chr 8: 48848222-49035296
- Description:
-
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
GATTGGY_NFY_Q6_01 , E2F1_Q4_01 , E2F4DP1_01 , E2F_Q6_01 , E2F_01 , E2F1_Q4 , E2F_Q6 , E2F1_Q6_01 , E2F_Q4 , E2F1DP2_01
- Cytogenetic Map:
-
8q11.21
GO Molecular Function
enzyme binding | nucleic acid binding | ribonucleotide binding | DNA-dependent protein kinase activity | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | DNA binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | double-stranded DNA binding | transcription factor binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding | RNA binding
GO Biological Process
positive regulation of immune response | negative regulation of phosphorylation | brain development | double-strand break repair | response to radiation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | telomere maintenance | negative regulation of immune system process | developmental process involved in reproduction | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | T cell lineage commitment | peptidyl-amino acid modification | regulation of cell aging | regulation of immune system process | response to hormone | negative regulation of cellular process | positive regulation of developmental process | telomere capping | cell differentiation | positive regulation of fibroblast proliferation | defense response | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | negative regulation of protein phosphorylation | regulation of G1/S transition of mitotic cell cycle | B cell differentiation | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | lymphocyte differentiation | mitotic DNA integrity checkpoint | lymphoid progenitor cell differentiation | negative regulation of G1/S transition of mitotic cell cycle | immune system development | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | anatomical structure homeostasis | intrinsic apoptotic signaling pathway | T cell receptor V(D)J recombination | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | cellular component organization | DNA-dependent protein kinase activity | T cell activation | head development | regulation of type I interferon production | response to stimulus | thymus development | pro-B cell differentiation | positive regulation of innate immune response | regulation of mitotic cell cycle phase transition | positive regulation of immune system process | response to stress | regulation of cell proliferation | double-strand break repair via alternative nonhomologous end joining | response to peptide | regulation of cell cycle phase transition | hematopoietic progenitor cell differentiation | protein serine/threonine kinase activity | programmed cell death | protein destabilization | activation of innate immune response | reproduction | rhythmic process | cellular nitrogen compound metabolic process | telomere organization | double-strand break repair via nonhomologous end joining | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | embryo development | DNA recombination | macromolecule modification | DNA repair | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | leukocyte differentiation | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | negative regulation of immunoglobulin production | regulation of protein stability | negative regulation of phosphate metabolic process | mitotic DNA damage checkpoint | multicellular organism development | response to activity | cellular response to peptide hormone stimulus | phosphorus metabolic process | cellular response to DNA damage stimulus | spleen development | cellular response to insulin stimulus | regulation of phosphorylation | somatic recombination of immunoglobulin gene segments | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cellular response to peptide | cell cycle | positive regulation of cellular metabolic process | negative regulation of response to gamma radiation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of transcription by RNA polymerase II | B cell activation | V(D)J recombination | cell proliferation | regulation of cellular protein metabolic process | phosphorylation | signal transduction involved in cell cycle checkpoint | programmed cell death involved in cell development | protein phosphorylation | response to gamma radiation | phosphate-containing compound metabolic process | mitotic G1 DNA damage checkpoint | chordate embryonic development | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | heart development | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | apoptotic signaling pathway | regulation of mitotic cell cycle | lymphocyte activation | T cell differentiation | activation of immune response | protein metabolic process | regulation of fibroblast proliferation | regionalization | regulation of growth | response to organic substance | gland development | regulation of innate immune response | T cell differentiation in thymus | protein ubiquitination | G1 DNA damage checkpoint | DNA metabolic process | response to insulin | anatomical structure development | mitotic cell cycle | metabolic process | cell fate commitment | immunoglobulin production | regulation of RNA biosynthetic process | negative regulation of programmed cell death | somatic diversification of immunoglobulins | negative regulation of mitotic cell cycle | positive regulation of cell death | immune response | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | cell death | animal organ development | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | positive regulation of cytokine production | negative regulation of cell aging | cell activation | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | negative regulation of protein metabolic process | B cell lineage commitment | negative regulation of cell cycle G1/S phase transition | positive regulation of developmental growth | negative regulation of cellular senescence | signaling | regulation of immunoglobulin production | somite development | positive regulation of growth | regulation of transcription, DNA-templated | cell development | regulation of developmental growth | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | somatic cell DNA recombination | signal transduction involved in DNA damage checkpoint | regulation of circadian rhythm | regulation of developmental process | kinase activity | segmentation | developmental process | organelle organization | peptidyl-serine phosphorylation | cellular protein modification process | mitotic G1/S transition checkpoint | positive regulation of transcription, DNA-templated | innate immune response | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | somitogenesis | signal transduction involved in mitotic G1 DNA damage checkpoint | central nervous system development | positive regulation of metabolic process | chromosome organization | immune system process | mitotic cell cycle checkpoint | cellular metabolic process | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | cellular response to organic substance | regulation of cell death | ectopic germ cell programmed cell death | regulation of smooth muscle cell proliferation | positive regulation of type I interferon production | DNA damage checkpoint | cell cycle checkpoint | negative regulation of cell death | circulatory system development | response to ionizing radiation | immunoglobulin V(D)J recombination | signal transduction | positive regulation of gene expression | macromolecule metabolic process | regulation of cellular senescence | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | DNA repair complex | cell | nuclear lumen | transcription factor complex | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | nonhomologous end joining complex | protein-DNA complex | nucleoplasm | nuclear chromosome | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | DNA-dependent protein kinase-DNA ligase 4 complex | cytosol | nuclear chromosome, telomeric region | intracellular | membrane
