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QuickView for PRL (gene)


Gene Symbol:
PRL Homo sapiens Homo sapiens
Full name:
prolactin
Synonyms:
GHA1, prolactin, decidual prolactin, growth hormone A1
Genomic Location:
Chr 6: 22395459-22405709
Description:
This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protei...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6p22.3





GO Molecular Function

signaling receptor binding | cytokine receptor binding | hormone activity | molecular function regulator | protein binding | receptor regulator activity | receptor ligand activity | prolactin receptor binding

GO Biological Process

response to extracellular stimulus | positive regulation of macromolecule biosynthetic process | response to nutrient levels | response to lipopolysaccharide | intracellular signal transduction | regulation of localization | establishment of localization | response to hormone | negative regulation of cellular process | positive regulation of developmental process | positive regulation of epithelial cell proliferation | JAK-STAT cascade | response to growth hormone | response to drug | response to antibiotic | positive regulation of cellular biosynthetic process | cellular process | secretion | localization | response to estradiol | female pregnancy | multicellular organismal reproductive process | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | cellular response to growth hormone stimulus | response to peptide hormone | regulation of angiogenesis | regulation of cellular process | parturition | regulation of metabolic process | cellular response to organonitrogen compound | regulation of vasculature development | response to stimulus | response to stress | positive regulation of JAK-STAT cascade | regulation of cell proliferation | ovulation cycle | negative regulation of angiogenesis | response to peptide | circadian rhythm | reproduction | response to alcohol | rhythmic process | response to molecule of bacterial origin | hormone activity | positive regulation of RNA biosynthetic process | molecular function regulator | response to ethanol | regulation of nucleic acid-templated transcription | response to nitrogen compound | cellular response to hormone stimulus | response to external biotic stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | cellular response to peptide hormone stimulus | mammary gland development | regulation of ossification | regulation of gene expression | positive regulation of secretion | response to lipid | cellular response to peptide | positive regulation of cellular metabolic process | regulation of pri-miRNA transcription by RNA polymerase II | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of STAT cascade | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | response to nutrient | cell proliferation | positive regulation of pri-miRNA transcription by RNA polymerase II | JAK-STAT cascade involved in growth hormone signaling pathway | response to toxic substance | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of lactation | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of RNA metabolic process | positive regulation of transport | multicellular organism reproduction | regulation of signaling receptor activity | receptor regulator activity | multicellular organismal response to stress | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of growth | response to organic substance | gland development | regulation of JAK-STAT cascade | lactation | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of endothelial cell proliferation | regulation of secretion | body fluid secretion | receptor ligand activity | organic substance metabolic process | animal organ development | regulation of endothelial cell proliferation | regulation of cell communication | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of developmental growth | growth hormone receptor signaling pathway | regulation of epithelial cell proliferation | cellular protein metabolic process | response to biotic stimulus | regulation of developmental process | developmental process | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | positive regulation of lactation | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | secretory vesicle | endomembrane system | vesicle | endosome | extracellular region | membrane-bounded organelle | endosome lumen | organelle | extracellular space | membrane-enclosed lumen | intracellular vesicle | intracellular