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QuickView for PSD95 (gene)


Gene Symbol:
DLG4 Homo sapiens Homo sapiens
Full name:
discs large MAGUK scaffold protein 4
Synonyms:
PSD95, SAP-90, SAP90, disks large homolog 4, Tax interaction protein 15, discs large homolog 4, post-synaptic density protein 95, synapse-associated protein 90
Genomic Location:
Chr 17: 7033933-7063781
Description:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, an...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17p13.1





GO Molecular Function

guanyl-nucleotide exchange factor activity | kinase binding | GTPase binding | D1 dopamine receptor binding | passive transmembrane transporter activity | enzyme binding | protein-containing complex binding | transmembrane transporter activity | ligand-gated ion channel activity | ion gated channel activity | signaling receptor binding | Ras GTPase binding | adrenergic receptor binding | molecular function regulator | protein domain specific binding | dopamine receptor binding | transporter activity | ion transmembrane transporter activity | scaffold protein binding | neuroligin family protein binding | protein binding | protein phosphatase binding | G-protein coupled receptor binding | Ras guanyl-nucleotide exchange factor activity | small GTPase binding | PDZ domain binding | channel activity | phosphatase binding | P2Y1 nucleotide receptor binding | ion channel activity | acetylcholine receptor binding | protein C-terminus binding | substrate-specific channel activity | glutamate receptor binding | ionotropic glutamate receptor binding | beta-1 adrenergic receptor binding

GO Biological Process

negative regulation of receptor internalization | purine ribonucleotide metabolic process | cell morphogenesis | dendritic spine development | guanyl-nucleotide exchange factor activity | GMP metabolic process | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | intracellular signal transduction | regulation of cell development | regulation of localization | positive regulation of peptidyl-tyrosine phosphorylation | establishment of localization | negative regulation of cellular process | positive regulation of developmental process | response to potassium ion | social behavior | response to metal ion | cell differentiation | nervous system development | AMPA glutamate receptor clustering | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | establishment or maintenance of apical/basal cell polarity | generation of neurons | membrane organization | neuromuscular process controlling balance | positive regulation of neurological system process | cellular process | localization | cellular homeostasis | cell projection morphogenesis | neurotransmitter-gated ion channel clustering | exploration behavior | negative regulation of receptor-mediated endocytosis | positive regulation of synaptic transmission | passive transmembrane transporter activity | nucleotide metabolic process | chemical synaptic transmission | neuron development | regulation of neuronal synaptic plasticity | dendritic spine organization | ribose phosphate metabolic process | learning | cellular response to potassium ion | positive regulation of protein kinase activity | macromolecule localization | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | regulation of neuron projection development | response to inorganic substance | negative regulation of cellular metabolic process | regulation of behavior | regulation of neurological system process | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | transmembrane transporter activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | ligand-gated ion channel activity | cellular aromatic compound metabolic process | cellular component organization | MAPK cascade | calcium ion homeostasis | cellular response to metal ion | response to stimulus | ion gated channel activity | purine nucleotide metabolic process | cell morphogenesis involved in neuron differentiation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | postsynaptic neurotransmitter receptor diffusion trapping | regulation of receptor internalization | receptor clustering | regulation of neurotransmitter receptor activity | cellular response to inorganic substance | cellular localization | cellular nitrogen compound metabolic process | negative regulation of transport | negative regulation of metabolic process | cellular component assembly | protein modification process | modulation of chemical synaptic transmission | purine nucleoside metabolic process | macromolecule modification | cell-cell signaling | GDP metabolic process | molecular function regulator | metal ion homeostasis | regulation of membrane potential | regulation of long-term neuronal synaptic plasticity | regulation of protein tyrosine kinase activity | system development | nitrogen compound metabolic process | regulation of signal transduction | modulation of excitatory postsynaptic potential | positive regulation of neuron projection development | multicellular organism development | phosphorus metabolic process | learning or memory | regulation of catalytic activity | regulation of phosphorylation | ion transmembrane transport | localization within membrane | regulation of receptor-mediated endocytosis | regulation of neuron differentiation | regulation of grooming behavior | protein localization to membrane | nervous system process | synaptic signaling | organophosphate metabolic process | nucleoside metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | small molecule metabolic process | positive regulation of cell projection organization | synapse organization | ion transmembrane transporter activity | positive regulation of neuron projection arborization | positive regulation of cell differentiation | nucleobase-containing small molecule metabolic process | cognition | locomotory behavior | regulation of cellular protein metabolic process | phosphorylation | protein phosphorylation | cell morphogenesis involved in differentiation | cation homeostasis | establishment or maintenance of cell polarity | phosphate-containing compound metabolic process | receptor localization to synapse | glutamate receptor clustering | protein localization to synapse | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | protein-containing complex localization | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | postsynaptic membrane organization | synaptic vesicle maturation | positive regulation of molecular function | neuron differentiation | regulation of signaling receptor activity | protein-containing complex assembly | protein metabolic process | positive regulation of protein modification process | nucleoside diphosphate metabolic process | regulation of kinase activity | anatomical structure development | positive regulation of neurogenesis | negative regulation of endocytosis | cell projection organization | metabolic process | positive regulation of cell development | developmental maturation | establishment or maintenance of epithelial cell apical/basal polarity | cellular protein localization | regulation of vesicle-mediated transport | chemical homeostasis | Ras guanyl-nucleotide exchange factor activity | behavior | cell adhesion | nucleobase-containing compound metabolic process | dendritic spine morphogenesis | neuron projection development | vocalization behavior | organic substance metabolic process | positive regulation of kinase activity | ion homeostasis | regulation of phosphate metabolic process | regulation of ion transmembrane transport | establishment of protein localization | vesicle organization | cell-cell adhesion | positive regulation of excitatory postsynaptic potential | dendrite morphogenesis | regulation of cell communication | transmembrane transport | signaling | neuromuscular process | cell development | regulation of endocytosis | regulation of transmembrane transporter activity | protein localization | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule localization | channel activity | regulation of NMDA receptor activity | dendrite development | regulation of nervous system development | regulation of developmental process | regulation of ion transport | developmental process | organelle organization | cellular protein modification process | carbohydrate derivative metabolic process | regulation of transport | regulation of cation channel activity | locomotory exploration behavior | cellular metal ion homeostasis | heterocycle metabolic process | regulation of glutamate receptor signaling pathway | ion channel activity | positive regulation of metabolic process | regulation of synaptic plasticity | positive regulation of neuron differentiation | ion transport | regulation of cell projection organization | cellular metabolic process | divalent inorganic cation homeostasis | substrate-specific channel activity | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

dendritic spine | exocytic vesicle | integral component of membrane | cytoplasmic side of plasma membrane | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | extrinsic component of membrane | potassium channel complex | endocytic vesicle membrane | somatodendritic compartment | organelle membrane | neuromuscular junction | postsynaptic specialization membrane | cytoplasmic vesicle | cell | cytoplasmic side of membrane | plasma membrane protein complex | extrinsic component of plasma membrane | intrinsic component of membrane | synaptic membrane | cytoplasm | cortical cytoskeleton | dendrite cytoplasm | cerebellar mossy fiber | intracellular organelle | receptor complex | endoplasmic reticulum | dendritic tree | main axon | presynapse | protein-containing complex | cell projection | secretory vesicle | postsynaptic membrane | endomembrane system | neuron spine | postsynapse | plasma membrane bounded cell projection cytoplasm | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | postsynaptic density membrane | vesicle | transport vesicle | postsynaptic density | asymmetric synapse | voltage-gated potassium channel complex | cytoplasmic region | integral component of plasma membrane | synaptic vesicle | juxtaparanode region of axon | cell cortex | membrane-bounded organelle | organelle | postsynaptic specialization | vesicle membrane | cell periphery | excitatory synapse | axon | basolateral plasma membrane | ionotropic glutamate receptor complex | transmembrane transporter complex | neuron projection terminus | cation channel complex | ion channel complex | cytosol | intracellular vesicle | cytoskeleton | endocytic vesicle | intracellular | cell junction | membrane | cytoplasmic vesicle membrane | AMPA glutamate receptor complex | intrinsic component of plasma membrane