QuickView for PSMA (gene)

Gene Symbol:

FOLH1 Homo sapiens

Full name:

folate hydrolase 1

Synonyms:

FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP, glutamate carboxypeptidase 2, N-acetylated alpha-linked acidic dipeptidase 1, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, cell growth-inhibiting gene 27 protein, folylpoly-gamma-glutamate carboxypeptidase, glutamate carboxylase II, glutamate carboxypeptidase II, membrane glutamate carboxypeptidase, prostate specific membrane antigen variant F, pteroylpoly-gamma-glutamate carboxypeptidase

Genomic Location:

Chr 11: 49124763-49186798

Description:

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervou...

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This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Cytogenetic Map:

11p11.12

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