QuickView for PSMC2;jsessionid=704E499B4FE4E691F2F70BFE2E967E00 (gene)

Gene Symbol:

PSMC2 Homo sapiens

Full name:

proteasome 26S subunit, ATPase 2

Synonyms:

MSS1, Nbla10058, S7, 26S proteasome regulatory subunit 7, 26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, mammalian suppressor of sgv-1 of yeast, protease 26S subunit 7, proteasome (prosome, macropain) 26S subunit, ATPase, 2, putative protein product of Nbla10058, testis secretory sperm-binding protein Li 197a

Genomic Location:

Chr 7: 102775325-102795892

Description:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which cont...

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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TEL2_Q6 ,  YCATTAA_UNKNOWN ,  CETS1P54_01 ,  SCGGAAGY_ELK1_02 ,  ELK1_02

Cytogenetic Map:

7q22.1

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