QuickView for PTBP2 (gene)

Gene Symbol:

PTBP2 Homo sapiens

Full name:

polypyrimidine tract binding protein 2

Synonyms:

PTBLP, brPTB, nPTB, polypyrimidine tract-binding protein 2, PTB-like protein, neural polypyrimidine tract binding protein, neurally-enriched homolog of PTB

Genomic Location:

Chr 1: 96959966-97052937

Description:

The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing resul...

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The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CRGAARNNNNCGA_UNKNOWN ,  NFMUE1_Q6 ,  AACTGAC_MIR223 ,  GGGACCA_MIR133A_MIR133B ,  CAGCACT_MIR5123P ,  E2F_01 ,  TTF1_Q6 ,  HNF4_01 ,  GGTGTGT_MIR329 ,  TITF1_Q3 ,  TGCCTTA_MIR124A ,  ACCAAAG_MIR9 ,  AGTCTTA_MIR499 ,  GACTGTT_MIR212_MIR132 ,  KCCGNSWTTT_UNKNOWN ,  PTF1BETA_Q6 ,  RNGTGGGC_UNKNOWN ,  HMGIY_Q6 ,  GTGCCTT_MIR506 ,  YY1_02 ,  SMAD4_Q6 ,  CTTTGT_LEF1_Q2 ,  P300_01 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-192 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-151 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-499 ,  Predicted Gene Targets for miR-378

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miRNA binding sites
(Source: miRecords):

hsa-miR-133b Targeted Genes

Cytogenetic Map:

1p21.3

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