QuickView for PTEN (gene)

Gene Symbol:

PTEN Homo sapiens

Full name:

phosphatase and tensin homolog

Synonyms:

10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, mitochondrial PTENalpha, mitochondrial phosphatase and tensin protein alpha, mutated in multiple advanced cancers 1, phosphatase and tensin-like protein, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Genomic Location:

Chr 10: 89613175-89718512

Description:

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most...

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This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCTGGAC_MIR198 ,  OCT1_05 ,  OCT1_B ,  RYTTCCTG_ETS2_B ,  OCT1_04 ,  OCT1_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  CTTTGCA_MIR527 ,  CEBP_Q2_01 ,  TGAGATT_MIR216 ,  OCT1_Q5_01 ,  OCT_C ,  GTACAGG_MIR486 ,  ACCAATC_MIR509 ,  ATAGGAA_MIR202 ,  CEBPDELTA_Q6 ,  OCT1_Q6 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  AAGGGAT_MIR188 ,  CTCTGGA_MIR520A_MIR525 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  GFI1_01 ,  GGCACTT_MIR519E ,  GGCAGCT_MIR22 ,  CEBP_Q3 ,  POU3F2_02 ,  GTGTCAA_MIR514 ,  GGCCAGT_MIR193A_MIR193B ,  TGATTTRY_GFI1_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  HIF1_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-486

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miRNA binding sites
(Source: miRecords):

hsa-miR-19a Targeted Genes ,  hsa-miR-214 Targeted Genes

Cytogenetic Map:

10q23.31

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