Correlation Engine 2.0
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QuickView for PTGS1 (gene)

Gene Symbol:
PTGS1 Homo sapiens Homo sapiens
Full name:
prostaglandin-endoperoxide synthase 1
COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS, prostaglandin G/H synthase 1, PGH synthase 1, cyclooxygenase-1, prostaglandin H2 synthase 1, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Genomic Location:
Chr 9: 124173050-124197802
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein...
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Canis lupus familiaris Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 9

GO Molecular Function

cofactor binding | peroxidase activity | cation binding | antioxidant activity | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | ion binding | organic cyclic compound binding | tetrapyrrole binding | prostaglandin-endoperoxide synthase activity | dioxygenase activity | heme binding | oxidoreductase activity, acting on peroxide as acceptor | metal ion binding | heterocyclic compound binding | oxidoreductase activity

GO Biological Process

peroxidase activity | defense response | cellular process | unsaturated fatty acid biosynthetic process | cellular detoxification | antioxidant activity | xenobiotic metabolic process | icosanoid biosynthetic process | cellular lipid metabolic process | response to stimulus | monocarboxylic acid metabolic process | cellular response to xenobiotic stimulus | response to stress | cyclooxygenase pathway | cellular response to toxic substance | blood circulation | cellular biosynthetic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | lipid metabolic process | regulation of blood pressure | small molecule metabolic process | response to oxidative stress | fatty acid biosynthetic process | biosynthetic process | lipid biosynthetic process | response to toxic substance | response to xenobiotic stimulus | inflammatory response | long-chain fatty acid metabolic process | carboxylic acid metabolic process | metabolic process | cellular oxidant detoxification | oxidation-reduction process | prostaglandin-endoperoxide synthase activity | prostaglandin metabolic process | organic substance metabolic process | dioxygenase activity | fatty acid metabolic process | icosanoid metabolic process | organic acid metabolic process | detoxification | prostaglandin biosynthetic process | oxidoreductase activity, acting on peroxide as acceptor | cellular metabolic process | oxidoreductase activity | arachidonic acid metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | intracellular | membrane