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QuickView for PTIP (gene)


Gene Symbol:
PAXIP1 Homo sapiens Homo sapiens
Full name:
PAX interacting protein 1
Synonyms:
CAGF28, CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2, PAX-interacting protein 1, PAX interacting (with transcription-activation domain) protein 1, PAX transcription activation domain interacting protein 1 like, protein encoded by CAG trinucleotide repeats
Genomic Location:
Chr 7: 154366333-154425615
Description:
This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 7
7q36.2





GO Molecular Function

protein binding

GO Biological Process

positive regulation of immune response | RNA metabolic process | adipose tissue development | double-strand break repair | response to radiation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | regulation of B cell activation | cell motility | intracellular signal transduction | peptidyl-amino acid modification | regulation of immune system process | positive regulation of developmental process | positive regulation of lymphocyte activation | histone modification | cell differentiation | epithelial cell migration | positive regulation of DNA recombination | positive regulation of histone H3-K36 methylation | regulation of organelle organization | regulation of isotype switching to IgG isotypes | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | regulation of transcription initiation from RNA polymerase II promoter | cellular process | localization | chromatin organization | positive regulation of immune effector process | positive regulation of adaptive immune response | epithelium migration | regulation of histone modification | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | tissue development | regulation of immune response | regulation of cellular process | regulation of metabolic process | regulation of protein complex assembly | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | positive regulation of response to DNA damage stimulus | regulation of histone methylation | response to stimulus | vasculature development | regulation of DNA recombination | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of immunoglobulin production | response to stress | endothelial cell migration | cellular nitrogen compound biosynthetic process | regulation of protein ubiquitination | tube morphogenesis | regulation of cell cycle phase transition | positive regulation of cell activation | cardiovascular system development | histone H3-K4 methylation | cellular nitrogen compound metabolic process | double-strand break repair via nonhomologous end joining | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | DNA recombination | macromolecule modification | blood vessel development | DNA repair | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | locomotion | regulation of cell cycle G2/M phase transition | system development | nitrogen compound metabolic process | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | multicellular organism development | histone methylation | cell migration | cellular response to DNA damage stimulus | positive regulation of chromosome organization | signal transduction in response to DNA damage | regulation of gene expression | methylation | cellular response to stress | positive regulation of cellular metabolic process | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | positive regulation of protein complex assembly | regulation of transcription by RNA polymerase II | biosynthetic process | regulation of cellular protein metabolic process | positive regulation of immunoglobulin mediated immune response | aromatic compound biosynthetic process | regulation of histone H3-K36 methylation | positive regulation of isotype switching | cell communication | regulation of cellular metabolic process | positive regulation of histone H3-K4 methylation | regulation of protein metabolic process | vasculogenesis | regulation of histone H3-K4 methylation | regulation of RNA metabolic process | positive regulation of protein acetylation | positive regulation of B cell activation | protein metabolic process | positive regulation of protein modification process | peptidyl-lysine methylation | DNA metabolic process | positive regulation of peptidyl-lysine acetylation | anatomical structure development | metabolic process | regulation of isotype switching | positive regulation of DNA-templated transcription, initiation | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | peptidyl-lysine modification | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | connective tissue development | histone lysine methylation | animal organ development | positive regulation of histone modification | gene expression | regulation of cell activation | chorion development | regulation of chromosome organization | transcription, DNA-templated | signaling | regulation of immunoglobulin production | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of DNA-templated transcription, initiation | protein methylation | regulation of developmental process | positive regulation of DNA metabolic process | developmental process | organelle organization | cellular protein modification process | regulation of histone acetylation | tube development | positive regulation of histone acetylation | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | positive regulation of isotype switching to IgG isotypes | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | positive regulation of histone methylation | cellular metabolic process | ameboidal-type cell migration | signal transduction by p53 class mediator | circulatory system development | positive regulation of protein ubiquitination | regulation of cellular component organization | response to ionizing radiation | positive regulation of transcription initiation from RNA polymerase II promoter | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | MLL3/4 complex | intracellular organelle | histone methyltransferase complex | protein-containing complex | methyltransferase complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear matrix | intracellular | nuclear periphery