QuickView for PTK2;jsessionid=96F0662CAA6F6637C4A32FF7D84E8831 (gene)

Gene Symbol:

PTK2 Homo sapiens

Full name:

protein tyrosine kinase 2

Synonyms:

FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, focal adhesion kinase 1, FADK 1, FAK-related non-kinase polypeptide, PTK2 protein tyrosine kinase 2, focal adhesion kinase isoform FAK-Del33, focal adhesion kinase-related nonkinase, protein phosphatase 1 regulatory subunit 71

Genomic Location:

Chr 8: 141737683-142080514

Description:

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies....

View Full Description

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAGCCAT_MIR135A_MIR135B ,  ETS_Q4 ,  TEL2_Q6 ,  WTGAAAT_UNKNOWN ,  CACCAGC_MIR138 ,  AP4_01 ,  GTCTTCC_MIR7 ,  IRF_Q6 ,  TGCCAAR_NF1_Q6 ,  YCATTAA_UNKNOWN ,  CTGCAGY_UNKNOWN ,  ICSBP_Q6 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  ETS1_B ,  CEBPGAMMA_Q6 ,  STTTCRNTTT_IRF_Q6

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-378

miRNA binding sites
(Source: miRecords):

hsa-miR-193a-3p Targeted Genes

Cytogenetic Map:

8q24.3

search → result