QuickView for PTK2B (gene)

Gene Symbol:

PTK2B Homo sapiens

Full name:

protein tyrosine kinase 2 beta

Synonyms:

CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK, protein-tyrosine kinase 2-beta, CAK-beta, FADK 2, PTK2B protein tyrosine kinase 2 beta, calcium-dependent tyrosine kinase, calcium-regulated non-receptor proline-rich tyrosine kinase, cell adhesion kinase beta, focal adhesion kinase 2, proline-rich tyrosine kinase 2, protein kinase B, related adhesion focal tyrosine kinase

Genomic Location:

Chr 8: 27224916-27372820

Description:

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream ...

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This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  GATTGGY_NFY_Q6_01 ,  TTTGCAC_MIR19A_MIR19B ,  TFIIA_Q6 ,  MYOD_01 ,  AML_Q6 ,  TGCACGA_MIR517A_MIR517C ,  CTTTGCA_MIR527 ,  SREBP1_Q6 ,  RYTGCNWTGGNR_UNKNOWN ,  TAATGTG_MIR323 ,  GGGYGTGNY_UNKNOWN ,  CAGGTA_AREB6_01 ,  RFX1_02 ,  CAGGTG_E12_Q6 ,  CTTTAAR_UNKNOWN ,  E47_01 ,  RNGTGGGC_UNKNOWN ,  NCX_01 ,  AATGTGA_MIR23A_MIR23B ,  TGACAGNY_MEIS1_01 ,  DR4_Q2 ,  PAX2_02 ,  COREBINDINGFACTOR_Q6 ,  CACTTTG_MIR520G_MIR520H ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323

Cytogenetic Map:

8p21.2

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