QuickView for PTPN1 (gene)

Gene Symbol:

PTPN1 Homo sapiens

Full name:

protein tyrosine phosphatase, non-receptor type 1

Synonyms:

PTP1B, tyrosine-protein phosphatase non-receptor type 1, protein tyrosine phosphatase, placental, protein-tyrosine phosphatase 1B

Genomic Location:

Chr 20: 48560298-48634495

Description:

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic ...

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The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ZIC1_01 ,  RSRFC4_01 ,  YTATTTTNR_MEF2_02 ,  RSRFC4_Q2 ,  GGGNRMNNYCAT_UNKNOWN ,  TGCCTTA_MIR124A ,  GGGCGGR_SP1_Q6 ,  YKACATTT_UNKNOWN ,  MGGAAGTG_GABP_B ,  OCT1_06 ,  GGCAGCT_MIR22 ,  SCGGAAGY_ELK1_02 ,  MEF2_03 ,  ZIC2_01 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  YWATTWNNRGCT_UNKNOWN ,  CAGCTG_AP4_Q5 ,  TGACATY_UNKNOWN ,  ACCATTT_MIR522

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

Cytogenetic Map:

20q13.13

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