QuickView for PTPN22;jsessionid=D33A7D86980C7A8EF5C5E02A0F4C70B5 (gene)
- Gene Symbol:
- PTPN22
Homo sapiens - Full name:
- protein tyrosine phosphatase, non-receptor type 22
- Synonyms:
- LYP, LYP1, LYP2, PEP, PTPN22.5, PTPN22.6, PTPN8, tyrosine-protein phosphatase non-receptor type 22, PEST-domain phosphatase, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, lymphoid-specific protein tyrosine phosphatase, protein tyrosine phosphatase, non-receptor type 22 (lymphoid), protein tyrosine phosphatase, non-receptor type 8
- Genomic Location:
- Chr 1: 114157960-114215857
- Description:
-
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1p13.2
GO Molecular Function
kinase binding | enzyme binding | SH3 domain binding | phosphatase activity | hydrolase activity | protein tyrosine phosphatase activity | catalytic activity | protein domain specific binding | ubiquitin-like protein ligase binding | phosphoprotein phosphatase activity | hydrolase activity, acting on ester bonds | protein binding | ubiquitin protein ligase binding | phosphoric ester hydrolase activity
GO Biological Process
positive regulation of immune response | negative regulation of leukocyte activation | regulation of JUN kinase activity | negative regulation of JNK cascade | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | negative regulation of MAPK cascade | negative regulation of immune system process | protein dephosphorylation | cellular response to muramyl dipeptide | immune response-regulating signaling pathway | response to lipopolysaccharide | negative regulation of peptide secretion | regulation of localization | immune response-regulating cell surface receptor signaling pathway | regulation of autophagy | regulation of immune system process | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of leukocyte cell-cell adhesion | regulation of MAP kinase activity | cell differentiation | immune response-activating cell surface receptor signaling pathway | T cell receptor signaling pathway | regulation of toll-like receptor 3 signaling pathway | response to drug | negative regulation of protein phosphorylation | positive regulation of phosphate metabolic process | negative regulation of protein secretion | positive regulation of protein secretion | regulation of toll-like receptor 4 signaling pathway | negative regulation of stress-activated protein kinase signaling cascade | cellular process | lymphocyte differentiation | negative regulation of signaling | negative regulation of T cell receptor signaling pathway | immune system development | negative regulation of secretion | positive regulation of nitrogen compound metabolic process | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of T cell receptor signaling pathway | negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | regulation of immune response | regulation of cellular process | leukocyte activation | cellular response to lipid | regulation of metabolic process | negative regulation of cytokine secretion | catabolic process | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | negative regulation of p38MAPK cascade | negative regulation of tumor necrosis factor production | positive regulation of cellular protein metabolic process | regulation of natural killer cell activation | cellular response to organonitrogen compound | T cell activation | phosphatase activity | regulation of peptide secretion | regulation of type I interferon production | response to stimulus | negative regulation of protein transport | regulation of interleukin-8 secretion | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | negative regulation of tumor necrosis factor superfamily cytokine production | negative regulation of lymphocyte activation | negative regulation of protein kinase activity | regulation of cell proliferation | positive regulation of protein polyubiquitination | regulation of protein ubiquitination | response to peptide | response to muramyl dipeptide | positive regulation of cytokine secretion | response to molecule of bacterial origin | immune response-activating signal transduction | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | hemopoiesis | positive regulation of toll-like receptor 4 signaling pathway | protein modification process | regulation of peptide transport | regulation of cell adhesion | macromolecule modification | protein tyrosine phosphatase activity | positive regulation of peptide secretion | leukocyte differentiation | regulation of cellular response to stress | response to nitrogen compound | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of secretion by cell | negative regulation of phosphate metabolic process | negative regulation of interleukin-6 production | multicellular organism development | negative regulation of catalytic activity | regulation of toll-like receptor signaling pathway | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of T cell activation | regulation of gene expression | positive regulation of secretion | response to lipid | cellular response to peptide | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | phosphoprotein phosphatase activity | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | regulation of cellular protein metabolic process | negative regulation of stress-activated MAPK cascade | negative regulation of interleukin-6 secretion | regulation of tumor necrosis factor production | phosphate-containing compound metabolic process | autophagy | negative regulation of autophagy | cellular response to drug | response to bacterium | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of natural killer cell proliferation | negative regulation of cell activation | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of establishment of protein localization | regulation of protein phosphorylation | negative regulation of MAP kinase activity | lipopolysaccharide-mediated signaling pathway | positive regulation of transport | regulation of nucleotide-binding oligomerization domain containing signaling pathway | lymphocyte activation | regulation of cytokine secretion | T cell differentiation | positive regulation of toll-like receptor 3 signaling pathway | activation of immune response | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of kinase activity | negative regulation of JUN kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | negative regulation of interleukin-8 secretion | phosphoanandamide dephosphorylation | regulation of secretion | regulation of protein K63-linked ubiquitination | organic substance metabolic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | regulation of cell activation | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | positive regulation of protein K63-linked ubiquitination | antigen receptor-mediated signaling pathway | negative regulation of interleukin-8 production | positive regulation of cytokine production | regulation of JNK cascade | cell activation | positive regulation of MAPK cascade | positive regulation of protein transport | negative regulation of protein metabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | dephosphorylation | negative regulation of molecular function | negative regulation of signal transduction | signaling | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | response to biotic stimulus | developmental process | cellular protein modification process | regulation of transport | peptidyl-tyrosine dephosphorylation | regulation of cell-cell adhesion | response to organonitrogen compound | regulation of B cell receptor signaling pathway | positive regulation of metabolic process | regulation of interferon-gamma production | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | positive regulation of type I interferon production | regulation of interleukin-6 production | positive regulation of interferon-gamma secretion | positive regulation of protein ubiquitination | positive regulation of toll-like receptor signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | regulation of p38MAPK cascade | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
cytoplasmic side of plasma membrane | intracellular membrane-bounded organelle | cell | cytoplasmic side of membrane | cytoplasm | intracellular organelle | plasma membrane | perinuclear region of cytoplasm | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane
