QuickView for PTPRJ;jsessionid=A13734933D0B92C4FE7E591F1893FF6D (gene)

Gene Symbol:

PTPRJ Homo sapiens

Full name:

protein tyrosine phosphatase, receptor type J

Synonyms:

CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, receptor-type tyrosine-protein phosphatase eta, CD148 antigen, DEP-1, HPTP eta, R-PTP-J, density-enhanced phosphatase 1, human density enhanced phosphatase-1, protein tyrosine phosphatase, receptor type, J polypeptide, protein-tyrosine phosphatase eta, susceptibility to colon cancer 1, mouse, homolog of

Genomic Location:

Chr 11: 47958686-48148970

Description:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III re...

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  MAZ_Q6 ,  GCANCTGNY_MYOD_Q6 ,  YATTNATC_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  LEF1_Q6 ,  LEF1_Q2 ,  CACCCBINDINGFACTOR_Q6 ,  TEF1_Q6 ,  CAGGTG_E12_Q6 ,  MYOD_Q6 ,  HIF1_Q5 ,  GCM_Q2 ,  OCT1_02 ,  WGGAATGY_TEF1_Q6 ,  MYOGENIN_Q6 ,  RGAGGAARY_PU1_Q6 ,  CTTTGT_LEF1_Q2 ,  NFKB_Q6_01 ,  NFKB_Q6 ,  NFKB_C ,  SP1_Q2_01 ,  LMO2COM_01

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Cytogenetic Map:

11p11.2

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