QuickView for PTS (gene)

Gene Symbol:

PTS Homo sapiens

Full name:

6-pyruvoyltetrahydropterin synthase

Synonyms:

PTPS, 6-pyruvoyl tetrahydrobiopterin synthase, PTP synthase

Genomic Location:

Chr 11: 111602309-111609903

Description:

The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involv...

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The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  TGCGCANK_UNKNOWN ,  TTGTTT_FOXO4_01

Cytogenetic Map:

11q23.1

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