QuickView for PUM1;jsessionid=025EF5FECEE11645C1A2480A8FD1E277 (gene)

Gene Symbol:

PUM1 Homo sapiens

Full name:

pumilio RNA binding family member 1

Synonyms:

HSPUM, PUMH, PUMH1, PUML1, pumilio homolog 1, pumilio-1

Genomic Location:

Chr 1: 31176940-31311151

Description:

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a tra...

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This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RYTTCCTG_ETS2_B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  STAT6_02 ,  CTTTGCA_MIR527 ,  PEA3_Q6 ,  TGTGTGA_MIR377 ,  TTTGTAG_MIR520D ,  GCCATNTTG_YY1_Q6 ,  CTTTGTA_MIR524 ,  SOX9_B1 ,  TTGGAGA_MIR5155P_MIR519E ,  TCCCRNNRTGC_UNKNOWN ,  YY1_Q6 ,  RFX1_02 ,  GGGCGGR_SP1_Q6 ,  GGCNKCCATNK_UNKNOWN ,  GTTGNYNNRGNAAC_UNKNOWN ,  SOX5_01 ,  ATACTGT_MIR144 ,  GGCNNMSMYNTTG_UNKNOWN ,  PTF1BETA_Q6 ,  CACGTTT_MIR302A ,  TTGTTT_FOXO4_01 ,  AP2REP_01 ,  YY1_02 ,  ACAWNRNSRCGG_UNKNOWN ,  E2F_Q2 ,  FOXM1_01 ,  SRY_02 ,  TCCCCAC_MIR491 ,  ELF1_Q6 ,  ACACTAC_MIR1423P ,  TCCAGAG_MIR518C ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-409-5p ,  Predicted Gene Targets for miR-491 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

1p35.2

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