QuickView for PURB (gene)

Gene Symbol:

PURB Homo sapiens

Full name:

purine rich element binding protein B

Synonyms:

PURBETA, transcriptional activator protein Pur-beta

Genomic Location:

Chr 7: 44882417-44891485

Description:

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replicatio...

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This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATAAGCT_MIR21 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TTTGCAG_MIR518A2 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TTTTGAG_MIR373 ,  CAGGTCC_MIR492 ,  AACTGAC_MIR223 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  TTTGTAG_MIR520D ,  AREB6_04 ,  GTACTGT_MIR101 ,  CAGCACT_MIR5123P ,  GTAAACC_MIR2995P ,  AATGGAG_MIR136 ,  ACCAATC_MIR509 ,  CATTTCA_MIR203 ,  GCACCTT_MIR18A_MIR18B ,  GTGACGY_E4F1_Q6 ,  CAGCTTT_MIR320 ,  GTCTTCC_MIR7 ,  CAGGGTC_MIR504 ,  ATTCTTT_MIR186 ,  GTAAGAT_MIR200A ,  ATGCTGC_MIR103_MIR107 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  ACTGCCT_MIR34B ,  ATGTTTC_MIR494 ,  E4F1_Q6 ,  TAATAAT_MIR126 ,  AGGTGCA_MIR500 ,  AP2_Q3 ,  GACTGTT_MIR212_MIR132 ,  GACAGGG_MIR339 ,  GGCAGCT_MIR22 ,  CCTGCTG_MIR214 ,  SCGGAAGY_ELK1_02 ,  GAGCCAG_MIR149 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  TACAATC_MIR508 ,  AAGCACT_MIR520F ,  ELK1_02 ,  ACAGGGT_MIR10A_MIR10B ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  GTTAAAG_MIR302B ,  CAATGCA_MIR33 ,  ACACTAC_MIR1423P ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-136 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-421 ,  Predicted Gene Targets for miR-455 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-499 ,  Predicted Gene Targets for miR-500 ,  Predicted Gene Targets for miR-504 ,  Predicted Gene Targets for miR-543 ,  Predicted Gene Targets for miR-544

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Cytogenetic Map:

7p13

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